...Inhibitor of Metalloprotease 1 Human Recombinant, HEK--性能参数...

Metalloproteinase inhibitor 1, Tissue inhibitor of metalloproteinases, TIMP-1, Erythroid-potentiating activity, EPA, Fibroblast Collagenase inhibitor, Collagenase inhibitor, TIMP1, CLGI, TIMP, EPO, HCI, FLJ90373. TIMP1 is a member of the TIMP family. TIMP1 is an inducible glycoprotein produced by various cell types. The TIMP1 glycoprotein is a natural inhibitor of the matrix metalloproteinases, which a group of peptidases involved in degradation of the extracellular matrix. TIMP1 binds in a reversible mode to MMPs, with regions in the N-terminal domain binding to the MMP substrate-binding site. On top of its inhibitory function against most of the known MMPs, TIMP1 is able to promote cell proliferation in a broad range of cell types, and may also have an anti-apoptotic role. Furthermore, TIMP1 has erthyroid-potentiating activity via translocation to the nucleus and also inhibits apoptosis in B-cells. The TIMP1 gene is situated within intron 6 of the synapsin I gene and is transcribed in the opposite direction. TIMP1 activity is dependent on the existence of disulfide bonds. TIMP1 transcription is extremely inducible in reaction to many cytokines and hormones. Increased TIMP1 levels are connecte

TIMP1 Human Recombinant produced in HEK-293 cells is a secreted protein with the sequence of Human TIMP-1 (amino acids Cys24-Ala207) and fused to a polyhistidine tag at the C-terminus.

It is recommended to reconstitute the lyophilized TIMP1 in sterile 18M?-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Lyophilized TIMP1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TIMP1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. The IC50 of 2.5-4 nM is measured by its ability to inhibit recombinant human MMP-2 cleavage of the colorimetric peptide substrate, Mca-PLGL-DpaAR-NH2. ProSpec\'s products are furnished for?LABORATORY RESEARCH?USE?ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. 北京启维益成科技有限公司（Beijing QiWei YiCheng Tech.,Ltd.(Qwbio)）成立于2005年12月，由从事生物领域多年销售经验人士创立。目前我公司已经与几十家著名的试剂供应商建立了长期稳定的合作关系，已成为众多国际知名品牌的中国总代理或一级代理商；并且为满足国内客户的最新需求，我们也与时俱进地不断与世界上更多的知名品牌洽谈合作代理事宜；企业的主要目标是把国外有特点的生物前沿产品引进中国，让国内科学研究机构和制药企业尽早使用上最新型的科研产品。我们代理的产品覆盖细胞生物学、植物学、分子生物学、免疫学、生物化学、蛋白组学。生物制药与诊断试剂研发生产等领域。细胞生物学包含细胞培养，细胞迁移，细胞信号转导等。植物学包含植物抗体，植物抗生素，植物组织培养试剂等。分子生物学包含表观遗传试剂盒，核酸提取，转染试剂等。免疫学包含抗体，各类检测试剂盒等。生物化学包含各类生化试剂，化学小分子，常规试剂等。蛋白组学包含不同种属的重组蛋白，天然提取蛋白，细胞因子等。生物制药与诊断试剂研发方面的试剂包含各类蛋白抑制剂，酶类等。在公司全体员工的共同努力和国外生产商的支持下，在业务上实现了迅猛发展，相继在上海、武汉、广州、长春、石家庄、哈尔滨等重点城市建立了分支机构或授权服务商，并以专业和优质的服务成为多家世界500强企业的中国区产品供应商，以及中国科学院科研采购平台的中标供货商。2008年以后业务的迅猛发展促进了启维益成内部组织架构的不断优化，我们建立了自己的网络销售平台，业务代表销售平台，针对科研客户与企业客户的不同需求，综合网络平台和业务代表平台的优点，启维益成创建了科研用户与工业客户两支独立的营销团队，分别配备不同的专业技术支持和客服人员，通过网络和业务代表，力求为不同类型的客户提供前沿专业的解决方案。 公司客户遍布中国生命科学基础研究、开发应用、制药、疾病诊断与控制、商品检验检疫、生物技术公司、食品安全以及农林畜牧业等诸多领域。 我们追求目的是与研究机构及合作伙伴之间诚信而专业的对话，力求建立长久合作。我们相信我们精心提供的高效、优质的产品和技术服务，会使您实验设计更有效，实验操作更简便，研究结果更可靠。 放眼未来，公司将努力实现更大的突破，将国外优秀产品不断引进国内，同时积极推动国内的产品销往世界各地