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Immunoway/CYCLOPAMINE/10mg 50mg 100mg/MC1267

    CYCLOPAMINE

    • Catalog No.：MC1267
    • Data Sheet
    • MSDS
    • Support
    • Description
    • References ( 0 )
    • Protocol
      • CasNo：
      • 4449-51-8
      • MolecularFormula：
      • C27H41NO2
      • Purity：
      • >98%
      • Target：
      • Hedgehog
      • IC50：
      • IC50: 46 nM (Hedgehog, in Hh cell assay)[1]
      • In Vitro：
      • Treatment with small molecule Hh inhibitors such as HhAntag and the natural product Cyclopamine, both binding to Smo, induces tumor remission in a genetic mouse model of medulloblastoma[1]. Cyclopamine is a Hedgehog (Hh) pathway antagonist. Cyclopamine suppresses cell growth. Cyclopamine (3 μM) suppression of Hh pathway activity and growth in digestive tract tumour cell lines correlates with expression of PTCHmRNA[2]. Cyclopamine is a steroidal alkaloid that inhibits Hh signalling through direct interaction with Smo[3].
      • In Vivo：
      • Cyclopamine causes durable regression of xenograft tumors. Tumors in Cyclopamine-treated animals, regress completely by 12 days[2]. Cyclopamine (1.2 mg) treatment blocks tumour formation of human pancreatic adenocarcinoma cells after transplantation into nude mice[3].
      • Fields：
      • Cyclopamine(11-Deoxojervine) is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM.
      • Specificity：
      • Target:Hedgehog. Fields: Cyclopamine(11-Deoxojervine) is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM.
      • Source：
      • Rabbit
      • Dilution：
      • IC50: 46 nM (Hedgehog, in Hh cell assay)[1]
      • Concentration：
      • >98%
      • Storage Stability：
      • 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
      • MolecularWeight(Da)：
      • 411.6
      • References：
      • [1]. Peukert S, et al. Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway. Bioorg Med Chem L
      • June 19-2018
      • WESTERN IMMUNOBLOTTING PROTOCOL
      • June 19-2018
      • IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL
      • June 19-2018
      • IMMUNOFLUORESCENCE PROTOCOL
      • September 08-2020
      • FLOW-CYTOMEYRT-PROTOCOL
      • July 13-2018
      • CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN
      • July 13-2018
      • CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN
      • July 13-2018
      • CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN
      • July 13-2018
      • Antibody-FAQs
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