产品资料

Immunoway/Tuberin/TSC2 (phospho-Ser1254) rabbit pAb/20ug 50ug 100ug/YP1538

Tuberin/TSC2 (phospho-Ser1254) rabbit pAb

Specificity：
This antibody detects endogenous levels ofHuman Mouse Rat Tuberin/TSC2 (phospho-Ser1254)

Purification：
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Background：
tuberous sclerosis 2(TSC2)Homo sapiensMutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Function：
alternative products:Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms,disease:Defects in TSC2 are a cause of lymphangioleiomyomatosis (LAM) [MIM:606690]. LAM is a progressive and often fatal lung disease characterized by a diffuse proliferation of abnormal smooth muscle cells in the lungs. It affects almost exclusively young women and can occur as an isolated disorder or in association with tuberous sclerosis complex.,disease:Defects in TSC2 are the cause of tuberous sclerosis complex (TSC) [MIM:191100]. The molecular basis of TSC is a functional impairment of the tuberin-hamartin complex. TSC is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. TSC is characterized by hamartomas (benign overgrowths predominantly of a cell or tissue type that occurs normally in the organ) and hamartias (de

Subcellular Location：
nucleus,cytoplasm,lysosome,Golgi apparatus,cytosol,membrane,TSC1-TSC2 complex,perinuclear region of cytoplasm,

Expression：
Blood,Brain,Endometrium,Epithelium,Lymph,Lymphoblast,Peripheral blood leukocyte,Pla