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| Product Name | Linear C5a Receptor Antagonist, human, ratFKP - (D - Cha) - Wr |
| Size | 1 mg |
| Catalog # | AS-65122 |
| US$ | $102 |
| Purity | % Peak Area By HPLC ≥ 95% |
This linear peptide is derived from the C-terminus of the chemokine, complement fragment 5 anaphylatoxin (C5a). This peptide functions to inhibit C5a binding and function at human and rat C5a receptors. C5a is crucial to triggering cellular immune responses and its overexpression is involved in arthritis, Alzheimers disease, cystic fibrosis, systemic lupus erythematosus, and other immunoinflammatory diseases | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Higginbottom, A. J Biol Chem 280, 17831 (2005); Buck, E. et al. PNAS 102, 2719 (2005). |
| Molecular Weight | 886.1 |
| FKP-(D-Cha)-Wr | |
| Sequence(Three-Letter Code) | H - Phe - Lys - Pro - D - Cha - Trp - D - Arg - OH |
| Product Citations | Spaan, A. et al. (2015).Differential Interaction of the Staphylococcal Toxins PantonValentine Leukocidin and γ-Hemolysin CB with Human C5a Receptors.JofI 195(3) 1034.DOI: https://doi.org/10.4049/jimmunol.1500604 |
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