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Xcessbio/GS143, IkappaB Ubiquitination Inhibitor -Xcessbio Biosciences Inc/2 mg solid/M60308-2s188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Xcessbio/GS143, IkappaB Ubiquitination Inhibitor -Xcessbio Biosciences Inc/2 mg solid/M60308-2s

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Product Information
Molecular Weight:466.46
Formula:C28H19FN2O4
Purity:≥98%
CAS#:916232-21-8
Solubility:DMSO up to 100 mM
Chemical Name:4-(3-benzyl-4-((5-(2-fluorophenyl)furan-2-yl)methylene)-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Storage:Powder:4oC 1 year. DMSO:4oC3 month;-20oC 1 year.

Biological Activity:GS143 is selective β-TrCP1 ligase inhibitor, inhibits IκBα ubiquitination with IC50 ~5.2 μM without affecting proteasome activity. It blocks LPS-induced expression of inflammatory cytokines in human myelomonocytic cells. It suppresses antigen-induced NFκB expression, inflammation and mucus production in airways of OVA-sensitized mice.

How to Use:In vitro:GS143 was used at 10-20 µM final concentration in various assays. In vivo: OVA-sensitized mice were given intranasally with GS143 (16 or 32 µg) and 2 h later, these mice were challenged with inhaled OVA.Reference:
  • 1.Hirose K, et al.GS143, an IkappaB ubiquitination inhibitor, inhibits allergic airway inflammation in mice. Biochem Biophys Res Commun. (2008) 374(3):507-11.
  • 2.Nakajima H, et al. A novel small-molecule inhibitor of NF-kappaB signaling. (2008) Biochem Biophys Res Commun. 368(4):1007-13.
GS143_spec.pdf
GS143_MSDS.pdf
Products are for research use only. Not for human use.

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