Adipogen/Colistin sulfate (USP Grade)/AG-CN2-0065-G005/5 g

More Information Product Details Synonyms Product Type Properties Formula MW CAS RTECS Source/Host Chemicals Purity Chemicals Appearance Solubility Biological Activity InChi Key Shipping and Handling Shipping Short Term Storage Long Term Storage Handling Advice Use/Stability Documents MSDS Product Specification Sheet Datasheet

Polymyxin E; Belcomycin; Colimycin

Chemical

2(C52H98N16O13) . 5(H2SO4) (unspec.)

2801.7

1264-72-8

TR1500000

Isolated from Bacillus polymyxa.

Mixture (primarly colistin A and B).

White to off-white powder.

Soluble in water.

Potency (dry basis) ≥15000U/mg

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AMBIENT

+4°C

+4°C

Keep cool and dry.

Stable for at least 2 years after receipt when stored at +4°C.

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• Very potent polymyxin antibiotic.
• Has only one amino acid difference compared to polymyxin B.
• Antimicrobial.
• Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations (Ca2+ and Mg2+) from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death.
• Used against multidrug-resistant Gram-negative bacterial infections.

Product References

Antimicrobial drugs, microorganisms, and phagocytes: P.J. van den Broek; Rev. Infect. Dis. 11, 213 (1989) (Review)

Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria: M.E. Evans, et al.; Ann. Pharmacother. 33, 960 (1999) (Review)

The clinical use of colistin in patients with cystic fibrosis: P. Beringer; Curr. Opin. Pulm. Med. 7, 434 (2001) (Review)

Update on antimicrobial agents: new indications of older agents: T.R. Pasquale & J.S. Tan; Expert Opin. Pharmacother. 6, 1681 (2005) (Review)

Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections: J. Li, et al.; Lancet Infect. Dis. 6, 589 (2006) (Review)

Polymyxin B: similarities to and differences from colistin (polymyxin E): A. Kwa, et al.; Expert Rev. Anti. Infect. Ther. 5, 811 (2007) (Review)

Colistin in the 21st century: R.L. Nation & J. Li; Curr. Opin. Infect. Dis. 22, 535 (2009) (Review)

New information about the polymyxin/colistin class of antibiotics: J. Molina, et al.; Expert Opin. Pharmacother. 10, 2811 (2009) (Review)

Colistin: new lessons on an old antibiotic: D. Yahav, et al.; Clin. Microbiol. Infect. 18, 18 (2012) (Review)