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| Description | iCRT3isanantagoNISTofWnt/β-cateninsignalingwithanIC50of8.2nMintheWntresponsiveSTF16-lucreporterassays. | ||
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| Targets |
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| Invitro | iCRT3isasmallmoleculeinhibitoroftheWntpathwaywhichbindstoβ-catenininterferingwithitsinteractionwithTCF.iCRT3significantlyreducestheLPS-inducedWnt/β-cateninactivityandalsoinhibitsTNF-αproductionandIκBdegradationinadose-dependentmanner.iCRT3doesnotinfluencethetranscriptionalactivityofFOP-Flashluciferasereporter,whichharborsmutationsintheDNAbindingsitesforTCF(β-catresponseelement),showingspecificityoftheresponse.ItinhibitscytokineproductioninLPS-stimulatedmacrophages[1][2]. | ||
| Invivo | IntraperitonealadministrationofiCRT3toC57BL/6mice,subjectedtocecalligationandpuncture-inducedsepsis,decreasestheplasmalevelsofproinflammatorycytokinesandorganinjuryMarkersinadose-dependentmanner.ThehistologicalintegrityofthelungsisimprovedwithiCRT3treatment,alongwithreducedlungcollagendepositionandapoptosis.Inaddition,iCRT3treatmentalsodecreasestheexpressionofthecytokines,neutrophilchemoattractants,aswellastheMPOactivityinthelungsofsepticmice[2]. |
Jackson/Peroxidase AffiniPure Goat Anti-Mouse IgG (H+L)/2.0 ml/115-035-003
Jackson/Peroxidase AffiniPure Goat Anti-Rabbit IgG (H+L)/2.0 ml/111-035-003
Qubit™ dsDNA BR Assay Kit Q32853现货
Invitrogen Q32855 Qubit™ RNA HS Assay Kit现货促销
LUCK-1G,D-Luciferin, Potassium Salt 钾盐现货
GoldBio/D-Luciferin, Sodium Salt (Proven and Published™)/LUCNA-1G/1 g