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Selleckchem/Kartogenin/S7658

DescriptionKartogeninisanactivatorofthesmad4/smad5pathway,andpromotestheselectivedifferentiationofmultipotentmesenchymalstemcellsintochondrocytes.
Targets
Smad4[1]()Smad5[1]()
Invitro

KartogenininduceschondrocytedifferentiationfromhMSCsbyenhancingthenuclearlocalizationofCBFβ,andprotectsarticularchondrocytes.[1]Kartogeninpromotesthetype-Icollagensynthesisofdermalfibroblastsviaactivationofthesmad4/smad5pathwaywithoutobviouscytotoxicityonfibroblasts’viABIlity,morphologyandsurvival.[2]

InvivoKartogeninpromotescartilagerepairinCollagenaseVII(10μM)–andsurgery(100μM)-inducedOAmodelsinmice.[1]Kartogenin(100nM)alsostimulatscollagensynthesisinthemousedermis.[2]Inaddition,Kartogeninstimulatesmouselimbskeletalgrowthandsynovialjointdevelopment.[3]
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