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LKT/TULOBUTEROL HYDROCHLORIDE/T8145/5 g

ProductIDT8145
CasNo.56776-01-3
Purity≥98%
  • Description
  • ProductInfo
  • ShippingandStorage
  • Downloads
  • References

Description

Tulobuterolisalong-actingβ2-adrenergicreceptoragoNISTthatisclinicallyusedinsomecountriestotreatchronicobstructivepulmonarydisorder(COPD)andasthma.Tulobuterolexhibitsbronchodilatory,anti-inflammatory,andantiviralactivities.Tulobuteroltreatspulmonarydisordersbyinducingrelaxationofairwaysmoothmusclecells.Intrachealepithelialcells,tulobuterolalsopreventsactivationofNF-κBanddecreaseslevelsofICAM-1,IL-1β,IL-6,andIL-8,inhibitingrhinovirusreplication.

ProductInfo

CasNo.

56776-01-3

Purity

≥98%

Formula

C12H18ClNO•HCl

FormulaWt.

264.19

IUPACName

2-(tert-butylamino)-1-(2-chlorophenyl)ethanol

Appearance

WhiteoralmostWhiteCrystallinePowder

ShippingandStorage

StoreTemp

Ambient

ShipTemp

Ambient

Downloads

MSDS

T8145MSDSPDF

InfoSheet

T8145InfoSheetPDF

References

YamayaM,NishimuraH,NADIneL,etal.Tulobuterolinhibitsrhinovirusinfectioninprimaryculturesofhumantrachealepithelialcells.PhysiolRep.2013Aug;1(3):e00041.PMID:24303127.

KatsunumaT,FujisawaT,NagaoM,etal.Effectsoftransdermaltulobuterolinpediatricasthmapatientsonlong-termleukotrienereceptorantagonisttherapy:resultsofarandomized,open-label,multicenterclinicaltrialinJapanesechildrenaged4-12years.AllergolInt.2013Mar;62(1):37-43.PMID:23000726.

TerpstraGK,RaaijmakersJA.Beta-agonisticpropertiesoftulobuterol,anewbeta-sympathicomimeticdrug,anditseffectsonpulmonarybeta-adrenoceptorcharacteristics.Lung.1990;168Suppl:179-85.PMID:1974673.

RuffF,ZanderJF,EdouteY,etal.Beta-2adrenergicresponsestotulobuterolinairwaysmoothmuscle,vascularsmoothmuscleandadrenergicnerves.JPharmacolExpTher.1988Jan;244(1):173-80.PMID:2826765.

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