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Bertin Pharma/TP53BP1 tudor-like region (human/14073/100 µg

ProductOverview:
Source:RecombinantN-terminalGST-taggedproteinexpressedinE.coli•Mr:42.6kDa•ThisproductcontainsthetudordomainofTP53BP1.BindingofTP53BP1todimethylatedlysine382onp53(p53K382me2),aswellashistoneH4K20me2,throughthetudordomain,hasbeenshowntobeimportantforTP53BP1localizationtoDNAdoublestrandbreaks.
Tudordomainsaresmallproteinstructuralmotifsof~50aminoacidsrelatedtothe“royalfamily”ofmethylreaders,whichalsoincludeschromo,MBT,PWWP,andAgenet-likedomains.Tudordomainsoccureitheralone,intandem,orwithotherdomains.TheyarefoundinmanyproteinsthatareinvolvedinRNAmetabolism,germcelldevelopment,transposonsilencing,DNAdamageresponse,histonemodification,andchromatinremodeling.Tudordomainsrecognizesymmetricmethylatedarginineormethylatedlysineresidues.TP53BP1bindsbothhistoneandnon-histonesubstrates.BindingofTP53BP1todimethylatedlysine382onp53(p53K382me2),aswellashistoneH4K20me2,throughthetudordomain,hasbeenshowntobeimportantforTP53BP1localizationtoDNAdoublestrandbreaks.ThisproductcontainsthetudordomainofTP53BP1.

Data:

Size:100µg
Shipping:dryice
StABIlity:Storeat-80degrees;shelflife180daysmaximumafterproduction
Formulation:50mMTris-HCl,pH8.0,containing150mMsodiumchlorideand20%glycerol
Purity:≥90%
CustomCode:3504001000
UNSPSCcode:12352204
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