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BioVision/AZ-3146/B1145/

Description:

AZ3146isapotentandselectiveMps1(monopolarspindle1)kinaseinhibitor(IC₅₀=35nM).Showsselectivityover46otherkinasesincludingaurorakinaseBandCdk1.AZ3146overridesspindleassemblycheckpointandalsointerfereswithchromosomealignment.IthasshowntoinhibittherecruitmentofMad1,2andcentromereproteinE(CENP-E)tokinetochores.
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AlternateName9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
AppearanceWhiteSolid
CAS#1124329-14-1
MolecularFormulaC₂₄H₃₂N₆O₃
MolecularWeight452.55
Purity≥98%byHPLC
SolubilityDMSO(>10mg/ml))
SMILESCN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC
InChi1S/C24H32N6O3/c1-28-12-10-17(11-13-28)33-18-8-9-19(21(14-18)32-3)26-23-25-15-20-22(27-23)30(24(31)29(20)2)16-6-4-5-7-16/h8-9,14-17H,4-7,10-13H2,1-3H3,(H,25,26,27)
InChiKeyYUKWVHPTFRQHMF-UHFFFAOYSA-N
PubChemCID56973724
MDLNumberMFCD18384959
HandlingProtectfromairandlight
StorageConditions-20°C
ShippingConditionsGelPack
USAGEForResearchUseOnly!NotForUseinHumans.