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BioVision/MAGEA3, human recombinant/9245/

Alternate Name CT1.3, HIP8, HYPD, MAGE3, MZ2 D
Gene Symbol MAGEA3
Gene ID 4102
Accession # NP_005353.1
Source E.coli
Appearance Liquid
Physical Form Description Liquid
Molecular Weight This protein is fused with a 6× His tag at N-terminus and has a calculated MW of 37.1 kDa.
Purity by SDS-PAGE ≥90%
Purity by ≥90%
Reconstitution Instructions In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol, 100mM NaCl
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSMPLEQRS QHCKPEEGLE ARGEALGLVG AQAPATEEQE AASSSSTLVE VTLGEVPAAE SPDPPQSPQG ASSLPTTMNY PLWSQSYEDS SNQEEEGPST FPDLESEFQA ALSRKVAELV HFLLLKYRAR EPVTKAEMLG SVVGNWQYFF PVIFSKASSS LQLVFGIELM EVDPIGHLYI FATCLGLSYD GLLGDNQIMP KAGLLIIVLA II
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Description:

Melanoma-associated antigen 3, also known MAGEA3, is a member of the MAGE gene family, which comprises 12 known genes, of which 6 are expressed in tumors. The MAGE genes were initially isolated from different kinds of tumors, and based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. MAGEA3 is a tumor-specific antigen widely expressed in solid and hematologic malignancies, but not in normal tissues, with the exception of testis and placenta. Therefore, MAGEA3 is an excellent candidate tumor antigen. Recombinant human MAGEA3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
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