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BioVision/Cathepsin K, Active, rat recombinant/7598/

Description:

CathepsinK,amemberofthepapaincysteineproteinasefamilyisthepredominantproteinaseresponsIBLefortheresorptionofthebonematrix.CathepsincleavesproteinssuchascollagentypeI,collagentypeIIandosteonectin,therebyplayingaroleinboneremodelingandresorptioninosteoporosis,osteolyticbonemetastasisandrheumatoidarthritis(BrommeandOkamoto,1995;Drake,F.etal1996;Bossardetal,1996).
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AlternateNameCTSK,CTSO,CTSO3
GeneSymbolCTSK
GeneID21975
Accession#O35186
SourceE.coli
AppearanceLiquid
PhysicalFormDescription0.5mg/mlsolutionin25mMNa2HPO4and500mMNaCl(pH7.0)with50%glycerol.
MolecularWeight23.5kDa(115-329aa)
PuritybySDS-PAGE≥90%
BIOLOGicalActivityThespecificactivityis>500mU/mg(1U=1µmole/min/mg)asmeasuredbyCathepsinKActivityAssayKit(Catalog#K141-100)
HandlingCentrifugethevialpriortoopening.
StorageConditions-80°C
ShippingConditionsDryIce
USAGEForResearchUseOnly!Nottobeusedinhumans