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| Synonyms | MonoclonalP4HBantibody,Anti-P4HBantibody,PHDBantibody,GITantibody,PHB-4,DSIantibody,PDIA1antibody,P4HB,PO4HBantibody,PHB4antibody,PO4DBantibody,PROHBantibody,PDIantibody,Procollagen-Proline2-Oxoglutarate4-DioxygenaseBetaPolypeptideantibody,ERBA2Lantibody,PHB-4antibody,PHB4 |
|---|---|
| CrossReactivity | Human |
| Applications | Useroptimized |
| Host | Mouse |
|---|---|
| Clone | 9C7 |
| Isotype | IgG |
| Form&Buffer | SuppliedinlyophilizedformwithPBSbuffer.Reconstitutein100ulofdistilledwater. |
| Concentration | 1mg/ml |
| Storage | Storeat4degCuntilreconstitution.Followingreconstitutionaliquotandfreezeat-200degCforlongtermstorage.Avoidrepeatedfreeze-thawcycles. |
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| BIOLOGicalSignificance | P4HBisthebetasubunitofprolyl4-hydroxylase,ahighlyabundantmultifunctionalenzymethatbelongstotheproteindisulfideisomerasefamily.Whenpresentasatetramerconsistingoftwoalphaandtwobetasubunits,thisenzymeisinvolvedinhydroxylationofprolylresiduesinpreprocollagen.Thisenzymeisalsoadisulfideisomerasecontainingtwothioredoxindomainsthatcatalyzetheformation,breakageandrearrangementofdisulfidebonds.OtherknownfunctionsincludeitsABIlitytoactasachaperonethatinhibitsaggregationofmisfoldedproteinsinaconcentration-dependentmanner,itsabilitytobindthyroidhormone,itsroleinboththeinfluxandeffluxofS-nitrosothiol-boundnitricoxide,anditsfunctionasasubunitofthemicrosomaltriglyceridetransferproteincomplex. |
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