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| Synonyms | Monoclonal FEN1 antibody, Anti-FEN1 antibody, Flap structure-specific endonuclease 1 antibody, FEN 1, MF1 antibody, FEN 1 antibody, FEN-1, FEN-1 antibody, FEN-1 antibody, FEN1, RAD2 antibody |
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| Specificity | Human FEN1 |
| Cross Reactivity | Human. Other species not studied |
| Applications | Dot Blot, ICC |
| Immunogen | FEN1 antibody was raised in mouse using recombinant Human Flap Structure-Specific Endonuclease 1 (Fen1) |
| Host | Mouse |
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| Clone | 2357C3a |
| Isotype | IgG1 |
| Method of Purification | FEN1 antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum. |
| Form & Buffer | FEN1 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ). |
| Concentration | 100 ug/ml |
| Storage | Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing. |
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| Biohazard Information | This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv |
| Usage Recommendations | To be optimized by the end user. |
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| Biological Significance | The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. |
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