Adipogen/BGG463/SYN-1226-M010/10 mg

More Information
Product Details
Synonyms	BGG-463
Product Type	Chemical
Properties
Formula	C₃₀H₂₉F₃N₆O₃
MW	578.6
CAS	890129-26-7
Purity Chemicals	≥95% (HPLC)
Appearance	Solid.
Solubility	Soluble in DMSO.
Declaration	Manufactured by SynKinase.
Other Product Data	Target: Src - Abl \| Kinase Group: PTK \| Substrate: Tyrosine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	MZZJNOOADWVFPD-UHFFFAOYSA-N
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

BGG463 (NVP-BGG463) was generated by a rational ‘hybrid design’ approach. Like Imatinib, BGG463 disrupts the assembly of the hydrophobic spine, a characteristic feature of the active state of several kinases, thereby locking the kinase in an inactive ‘DFG-out’ conformation. BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC₅₀) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.

Product References

Rational design of T315I BCR-Abl inhibitors for the treatment of drug-resistant chronic myelogenous leukemia (CML): BGG463: P.W. Manley, et al.; Chimia (Aarau) 62, 579 (2008)

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Adipogen/BGG463/SYN-1226-M010/10 mg