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Adipogen/UbcH1 (human) (rec.)/AG-40T-0409-C100/100 µg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Adipogen/UbcH1 (human) (rec.)/AG-40T-0409-C100/100 µg

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ProductDetails
SynonymsUbiquitin-conjugatingEnzymeE2;E2-25K;Hip2;HYPG;LIG;UBE2K;UBE2K-25K;Huntingtin-interactingProtein2
ProductTypeProtein
Properties
Source/HostE.coli
SequenceHumanUbcH1(AccessionNr.P61086).
CrossreactivityHuman
FormulationLiquid.In50mMHEPESpH7.5,150mMNaCl,1mMTCEP.
OtherProductDataUse:Memberoftheubiquitin­conjugating(E2)enzymefamilythatreceivesubiquitinfromaubiquitin­activating(E1)enzymeandsubsequentlyinteractswithaubiquitinligase(E3)toconjugateubiquitintosubstrateproteins.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof0.1-­1μM.
DeclarationManufacturedbyBostonBiochem
ShippingandHandling
ShippingDRYICE
ShortTermStorage-20°C
LongTermStorage-80°C
HandlingAdviceAliquottoavoidfreeze/thawcycles.
Use/StABIlityStableforatleast1yearafterreceiptwhenstoredat-80°C.
Documents
MSDSNo
ProductSpecificationSheet
DatasheetDownloadPDF
Ubiquitin-conjugatingEnzymeE2K(UBE2K),alsoknownasE2-25K,HIP2,andLIG,isa200aminoacid(aa)proteinwithapredictedmolecularweightof25kDa.HumanandmouseUBE2Kshare100%aasequenceidentity.Similartootherubiquitin-conjugating(E2)enzymes,UBE2K/E2-25Kcontainsaconservedubiquitin-conjugatingdomainbutisuniqueinthatitalsohasaC-terminal,non-covalentubiquitinbindingsurfacetermedtheubiquitin-associateddomainbetweenaaresidues160and200.UBE2K/E2-25KmediatestheelongationofLys48-linkedpoly-ubiquitinchains.UBE2K/E2-25Kcatalyticactivitycanbemodulatedbythepost-translationaladditionofSUMOatLys14.SubstratesincludetheHuntingtinproteinandthetumorsuppressorRB1.UBE2K/E2-25Kiswidelyexpressed,withhighestlevelsfoundinthebraincortexandstriatum,anddysregulatedUBE2K/E2-25KisimplicatedinpolyglutaminediseasesandAlzheimer"sdisease.
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