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Adipogen/YM201636 hydrochloride/SYN-1094-M005/5 mg

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ProductDetails
SynonymsYM-201636
ProductTypeChemical
Properties
FormulaC25H21N7O3.HCl
MW467.4.36.5
CAS371942-69-7(freebase)
PurityChemicals≥95%
AppearanceSolid.
SolubilitySolubleinDMSO.Slightlysoluble(<1mg l)="" in="" ethanol.="">
DeclarationManufacturedbySynKinase.
OtherProductDataTarget:PIKfyve|KinaseGroup:LipidKinase|Substrate:Lipid

ClickhereforOriginalManufacturerProductDatasheet
Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.
InChiKeyFZSHKSKFIDALKO-UHFFFAOYSA-N
ShippingandHandling
ShippingAMBIENT
ShortTermStorage+4°C
LongTermStorage-20°C
Use/StABIlityStableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
YM-201636isacell-permeableandselectiveinhibitorofPIKfyve(IC(50)of33nM).Itdisruptsretroviralbuddingfromcells,apparentlybyinterferingwiththeendosomalsortingcomplexrequiredfortransport(ESCRT)machinery.InADIpocytes,YM-201636alsoinhibitsbasalandinsulin-activated2-deoxyglucoseuptake(IC(50)of54nM).
ProductReferences
  1. AselectivePIKfyveinhibitorblocksPtdIns(3,5)P(2)productionanddisruptsendomembranetransportandretroviralbudding:H.B.Jefferies,etal.;EMBORep.9,164(2008)
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