产品资料

Adipogen/Ponasterone A/AG-CN2-0053-M001/1 mg

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ProductDetails
Synonyms	PonA;25-Deoxy-20-hydroxyecdysone;25-Deoxyecdysterone;AI3-44686;2β,3β,14α,20R,22R-Pentahydroxy-5β-cholest-7-en-6-one
ProductType	Chemical
Properties
Formula	C₂₇H₄₄O₆
MW	464.6
MerckIndex	14:7588
CAS	13408-56-5
Source/HostChemicals	Semi-synthetic.
PurityChemicals	≥95%(HPLC)
Appearance	Whitetooff-whitepowder.
Solubility	Solubleinaceticacid,ethanol,methanolorDMSO.Insolubleinwater.
Identity	Identitydeterminedby¹H-and¹³C-NMR.
OtherProductData	Topreparea1mMstocksolution(1.1mM)in100%ethanol:Add2mlof100%ethanolto1mg(2µmol).Gentlymixtodissolvetheproduct(5to10min.).Donotheatsolutiontodissolvetheproduct.Storethe1mMstocksolutionat+4°Corat-20°C.
InChiKey	PJYYBCXMCWDUAZ-JJJZTNILSA-N
ShippingandHandling
Shipping	AMBIENT
ShortTermStorage	+4°C
LongTermStorage	-20°C
Use/StABIlity	Stableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDS	DownloadPDF
ProductSpecificationSheet
Datasheet	DownloadPDF

Amemberoftheecdysteroidfamily.
Ecdysonereceptor(EcR)agoNIST.
AnalogofecdysonewithsimilarpropertiestomuristeroneA.
Functional,reliableandeconomicalsubstituteformuristeroneAasaninducerfortheecdysone-inducIBLemammalianexpressionsystem.
Inducesexpressionofβ-galactosidasetolevelssimilartothoseobtainedwithmuristeroneAinduction.
Potentcompoundforecdysteroidactivity.
Insectsteroidhormoneinvolvedinregulatingmetamorphosis.

ProductReferences

ExtractionofponasteroneAandecdysteronefrompodocarpaceaeandrelatedplants:S.Imaietal.;Steroids10,557(1967)
Ecdysonesandanalogs:effectsondevelopmentandreproductionofinsects:W.E.Robbins,etal.;Science161,1158(1968)
TheuptakeandreleaseofponasteroneAbytheKccelllineofDrosophilamelanogaster:C.Beckers,etal.;Mol.Cell.Endocrinol.17,51(1980)
Pastandpresentstudieswithponasterones,thefirstinsectmoltinghormonesfromplants:K.Nakanishi;Steroids57,649(1992)
Identificationofligandsandcoligandsfortheecdysone-regulatedgeneswitch:E.Saez,etal.;PNAS97,14512(2000)
Mammalian5"(3")-deoxyribonucleotidase,CDNAcloning,andoverexpressionoftheenzymeinEscherichiacoliandmammaliancells:C.Rampazzo,etal.;J.Biol.Chem.275,5409(2000)
Sustainedmammarygland-directed,ponasteroneA-inducibleexpressionintransgenicmice:C.Albanese,etal.;FASEBJ.14,877(2000)
Theecdysoneinduciblegeneexpressionsystem:unexpectedeffectsofmuristeroneAandponasteroneAoncytokinesignalinginmammaliancells:S.Constantino,etal.;Eur.CytokineNetw.12,365(2001)
Recentadvancesininducibleexpressionintransgenicmice:C.Albanese,etal.;Semin.Cell.Dev.Biol.13,129(2002)
PotentandselectivepartialecdysoneagonistactivityofchromafenozideinSf9cells:T.Toya,etal.;BBRC292,1087(2002)
DevelopmentofaponasteroneA-induciblegeneexpressionsystemforapplicationinculturedskeletalmusclecells:Y.Y.Xiao,etal.;Int.J.Biochem.Cell.Biol.35,79(2003)
DevelopmentofaninvitroReporterGeneAssayforScreeningtheEcdysoneReceptorAgonistsinMysidCrustacean:M.Hirano,etal.;Terrapub141(2010)