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TOKU-E/Quinupristin mesylate/Q008/5 mg

Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogrycin B, pristinamycin IA, streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone. Addition of quinucidinylthiol to the methylene group affords quinupristin. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Quinupristin is used commercially in synergistic combination with dalfopristin (30:70). There is little published data on the synthesis, biological or antibiotic activity of quinupristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.

Quinupristin is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    120138-50-3

    Molecular Formula

    C54H71N9O13S2

    Molecular Weight

    1118.3

    Storage Conditions

    -20°C

Specifications:

    Appearance

    White to fawn solid

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