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TOKU-E/Amphotericin B, USP/1 g/A007-1 g

Amphotericin B, USP is a polyene antifungal or antimycotic compound derived fromStreptomyces nodosus. It is used to control contamination from fungi, viruses and protozoa.

TOKU-E offers 3 forms of Amphotericin B:

  • Amphotericin B, USP (A007)
  • Amphotericin B, EP (A064)
  • Amphotericin B, solubilized (A008)

The compound is nearly insoluble in water at pH 6-7 (but is soluble at pH 2 or 11). It is soluble in dimethyl sulfoxide and dimethylformamide.

Amphotericin B, USP conforms to United States Pharmacopoeia specifications.

    CAS Number

    1397-89-3

    Molecular Formula

    C47H73NO17

    Molecular Weight

    924.08

    Mechanism of Action

    Amphotericin B associates with membrane sterols (ergosterol in fungal cell membranes, and cholesterol in mammalian cell membranes). Amphotericin B forms a pore in these membranes resulting in leakage of essential ions and ultimately cell death.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.1050

    Spectrum

    Amphotericin B is active against mammalian cells, fungi, viruses, and protozoa.Amphotericin B is not toxic to bacteria due to their lack of sterols.

    The following represents MIC susceptibility data for amphotericin B against common fungal pathogens:

    • Candida albicans- 0.001 - 321 μg/mL
    • Candida krusei- 0.001 - 16 μg/mL
    • Coccidioides immitis- 0.0625 - 2 μg/mL
    • Cryptococcus neoformans- 0.2 - 39 μg/mL
    • Fusarium oxysporum- 0.75 - 125 μg/mL

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