Interleukin15isacytokinewithstructuralsimilaritytoIL-2.LikeIL-2,IL-15bindstoandsignalsthroughtheIL-2/IL-15betachain(CD122)andthecommongammachain(gamma-C,CD132).IL-15issecretedbymononuclearphagocytes(andsomeothercells)followinginfectionbyvirus(es).Thiscytokineinducescellproliferationofnaturalkillercells;cellsoftheinnateimmunesystemwhoseprincipalroleistokillvirallyinfectedcells.Interleukin15(IL-15)regulatesTandnaturalkiller(NK)cellactivationandproliferation.SurvivalsignalsthatmaintainmemoryTcellsintheabsenceofantigenareprovidedbyIL-15.ThiscytokineisalsoimplicatedinNKcelldevelopment.Inrodentlymphocytes,IL-15preventsapoptosisbyinducinganapoptosisinhibitor,BCL2L1/BCL-x(L).IL-15hasbeenshowntoenhancetheanti-tumorimmunityofCD8+Tcellsinpre-clinicalmodels.AphaseIclinicaltrialtoevaluatethesafety,dosing,andanti-tumorefficacyofIL-15inpatientswithmetastaticmelanomaandrenalcellcarcinoma(kidneycancer)hasbeguntoenrollpatientsattheNationalInstitutesofHealth.
ThiswasdeterminedbySDS-PAGE.
Determinedbythedose-dependentstimulationoftheproliferationofCTLL-2cells.
SeeCertificateofAnalysisforreconstitutioninstructionsandspecificconcentrations.
LyophilizedProteinshouldbestoredat-20°orlowerforlongtermstorage.Uponreconstitution,workingaliquotsshouldbestoredat-20°or-70°.Avoidrepeatedfreeze-thawcycles.
Jackson/Peroxidase AffiniPure Goat Anti-Mouse IgG (H+L)/2.0 ml/115-035-003
Jackson/Peroxidase AffiniPure Goat Anti-Rabbit IgG (H+L)/2.0 ml/111-035-003
Qubit™ dsDNA BR Assay Kit Q32853现货
Invitrogen Q32855 Qubit™ RNA HS Assay Kit现货促销
LUCK-1G,D-Luciferin, Potassium Salt 钾盐现货
GoldBio/D-Luciferin, Sodium Salt (Proven and Published)/LUCNA-1G/1 g