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HumanZyme/BMP-6 (Bone Morphogenetic Protein-6)/HZ-7187/10 µg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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HumanZyme/BMP-6 (Bone Morphogenetic Protein-6)/HZ-7187/10 µg

ProductDescription:

TGF-βfamilymembersarekeymodulatorsofcellproliferation,differentiation,matrixsynthesis,andapoptosis.Asimpliedbytheirname,BMPsinitiate,promote,andregulatethedevelopment,growth,andremodelingofboneandcartilage.Inadditiontothisrole,BMPsarealsoinvolvedinprenataldevelopmentandpostnatalgrowth,remodeling,andmaintenanceofavarietyofothertissuesandorgans.IncreasingevidenceindicatesthatBMP-Smadsignalinghasatumorsuppressingactivity,andthatBMPscaninhibittumorgrowth.BMP-6isabnormallyexpressedinbreastcancercelllines,however,itsfunctioninpromotingbreastcancerdevelopmentisunknown.ThematureandfunctionalformofBMP-6isahomodimeroftwoidentical139aminoacidpolypeptidechainslinkedbyasingledisulfidebond.EachmonomerisexpressedastheC-terminalpartofaprecursorpolypeptide,whichcontainsa20aminoacidsignalpeptideanda354aminoacidpropeptide.Thisprecursorundergoesintracellulardimerization,anduponsecretionitisprocessedbyafurin-typeprotease.

TechnicalSpecifications:

  • Species:Human
  • Expression:HEK293CellExpressed
  • Activity:Typically0.03-0.06μg/mlED50
  • Purity:≥95%
  • Endotoxin:<1.0EU/μg
  • MolecularMass:26.2kDa
  • Formulation:10mMTris,pH9.0
  • CountryofOrigin:USA

PurityConfirmation:

ThiswasdeterminedbySDS-PAGEgelandHPLCanalysis.

ActivityAssay:

DeterminedbyitsABIlitytoinducealkalinephosphataseproductionbyATDC-5cells.

AASequence:

VSSASDYNSSELKTACRKHELYVSFQDLGW
QDWIIAPKGYAANYCDGECSFPLNAHMNAT
NHAIVQTLVHLMNPEYVPKPCCAPTKLNAI
SVLYFDDNSNVILKKYRNMVVRACGCH

ReconstitutionBuffer:

Centrifugethevialpriortoopening.Reconstituteinwatertoaconcentrationof0.1-1.0mg/ml.Donotvortex.

Storage:

Forextendedstorage,itisrecommendedtofurtherdiluteinabuffercontainingacarrierprotein(example0.1%HSA)andstoreinworkingaliquotsat-20°Cto-80°C.

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