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HumanZyme/BMP-3 (Bone Morphogenetic Protein-3)/HZ-7181/50 µg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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HumanZyme/BMP-3 (Bone Morphogenetic Protein-3)/HZ-7181/50 µg

ProductDescription:

TGFbetafamilymembersarekeymodulatorsofcellproliferation,differentiation,matrixsynthesis,andapoptosis.Asimpliedbytheirname,BMPsinitiate,promote,andregulatethedevelopment,growth,andremodelingofboneandcartilage.Inadditiontothisrole,BMPsarealsoinvolvedinprenataldevelopmentandpostnatalgrowth,remodelingandmaintenanceofavarietyofothertissuesandorgans.BMP-3isabundantlyfoundinadultboneand,toalesserextent,fetalcartilage.BMP-3inhibitsosteogenesisandboneformationbyactivatingasignalingcascadethatantagonizesthesignalingofpro-osteogenicBMPs.RecombinantHumanBMP-3isadisulfide-linkedhomodimericproteinthatcorrespondstoresidues361to472ofthe472aminoacidBMP-3precursorprotein.

TechnicalSpecifications:

  • Species:Human
  • Expression:E.coliCellExpressed
  • Purity:≥95%
  • Endotoxin:<1.0EU/μg
  • MolecularMass:25.2kDa
  • CountryofOrigin:USA

PurityConfirmation:

ThiswasdeterminedbySDS-PAGEgelandHPLCanalysis.

ActivityAssay:

DeterminedbyitsABIlitytoinhibitBMP-2-inducedalkalinephosphataseproductionbyATDC-5cells.

AASequence:

MQWIEPRNCARRYLKVDFADIGWSEWIISP
KSFDAYYCSGACQFPMPKSLKPSNHATIQS
IVRAVGVVPGIPEPCCVPEKMSSLSILFFD
ENKNVVLKVYPNMTVESCACR

ReconstitutionBuffer:

Centrifugethevialpriortoopening.Reconstituteinwatertoaconcentrationof0.1-1.0mg/ml.Donotvortex.

Storage:

Forextendedstorage,itisrecommendedtofurtherdiluteinabuffercontainingacarrierprotein(example0.1%HSA)andstoreinworkingaliquotsat-20°Cto-80°C.

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