TGFbetafamilymembersarekeymodulatorsofcellproliferation,differentiation,matrixsynthesis,andapoptosis.Asimpliedbytheirname,BMPsinitiate,promote,andregulatethedevelopment,growth,andremodelingofboneandcartilage.Inadditiontothisrole,BMPsarealsoinvolvedinprenataldevelopmentandpostnatalgrowth,remodelingandmaintenanceofavarietyofothertissuesandorgans.BMP-3isabundantlyfoundinadultboneand,toalesserextent,fetalcartilage.BMP-3inhibitsosteogenesisandboneformationbyactivatingasignalingcascadethatantagonizesthesignalingofpro-osteogenicBMPs.RecombinantHumanBMP-3isadisulfide-linkedhomodimericproteinthatcorrespondstoresidues361to472ofthe472aminoacidBMP-3precursorprotein.
ThiswasdeterminedbySDS-PAGEgelandHPLCanalysis.
DeterminedbyitsABIlitytoinhibitBMP-2-inducedalkalinephosphataseproductionbyATDC-5cells.
MQWIEPRNCA | RRYLKVDFAD | IGWSEWIISP |
KSFDAYYCSG | ACQFPMPKSL | KPSNHATIQS |
IVRAVGVVPG | IPEPCCVPEK | MSSLSILFFD |
ENKNVVLKVY | PNMTVESCAC | R |
Centrifugethevialpriortoopening.Reconstituteinwatertoaconcentrationof0.1-1.0mg/ml.Donotvortex.
Forextendedstorage,itisrecommendedtofurtherdiluteinabuffercontainingacarrierprotein(example0.1%HSA)andstoreinworkingaliquotsat-20°Cto-80°C.
Jackson/Peroxidase AffiniPure Goat Anti-Mouse IgG (H+L)/2.0 ml/115-035-003
Jackson/Peroxidase AffiniPure Goat Anti-Rabbit IgG (H+L)/2.0 ml/111-035-003
Qubit™ dsDNA BR Assay Kit Q32853现货
Invitrogen Q32855 Qubit™ RNA HS Assay Kit现货促销
LUCK-1G,D-Luciferin, Potassium Salt 钾盐现货
GoldBio/D-Luciferin, Sodium Salt (Proven and Published)/LUCNA-1G/1 g