Deprecated: Creation of dynamic property cls_session::$session_data_table is deprecated in /www/sites/www.188bio.com/index/systems/cls_session.php on line 49
Bpsbioscience/PAK6, His-tag/40081/10 µg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
您好,欢迎您进入188进口试剂采购网网站! 服务热线:4000-520-616
蚂蚁淘商城 | 现货促销 | 科研狗 | 生物在线
产品资料

Bpsbioscience/PAK6, His-tag/40081/10 µg

Species:Human
HostSpecies:E.coli
MW:34.2kDa
Genbank#:NM_020168
Tag(s):N-terminalHis-tag
a.a:385–680
Background:
PAK6isaSer/ThrproteinkinasethatisamemberofthePAK(p21-activatedkinase)familythatareimplicatedintheregulationofanumberofcellularprocesses,includingCytoskeletonrearrangement,apoptosisandtheMAPkinasesignalingpathway.PAK6ishighlyexpressedinthetestisandprostatetissuesandinteractswiththeandrogenreceptor(AR).Inresponsetoandrogen,PAK6cotranslocateintothenucleuswithAR.PAK6isweaklyexpressedinnormalprostateepitheliumbuttheexpressionisincreasedinprimaryandmetastaticprostatecancercellsandisfurtherincreasedintumorsthatrelapseafterandrogendeprivationtherapy.
Description:
HumanPAK6(GenBankAccessionNo.NM_020168),a.a.385-680,MW=34.2kDa,expressedinE.coli.
Purity:
≥95%
SpecificActivity:
2.1nmoles/min/µg
AssayConditions:
AnalysisofenzymaticactivitywasperformedaccordingtoZlyteassayprotocol(Invitrogen).PAK5wasincubatedinabuffercontaining50mMHEPES(pH7.5),10mMMgCl2,1mMEGTA,200μMATP,0.01%Brij-35,and2μMsubstrate(SER/THR20,Invitrogen)atroomtemperaturefor1hour.Developersolutionwasaddedtoreactionfor1houratRT.Fluorescencewasdetectedusingλexc=460±40nmandλem=528±20nm
Formulation:
25mMTris-HCl,pH8,150mMNaCl,10%glycerol,5mMDTT
Format:
Aqueousbuffersolution
Storage/StABIlity:
>6monthsat–80°C.
Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.Kaur,R.,etal.,Prostate68(14),1510-1516(2008).
2.Hosgood,H.D.etal.,Carcinogenesis29(10),1938-1943(2008).
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Kinase/Serine-Threonine
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
相关产品
最新签约

SBI

anchormolecular

Aviscera

Prospec

MedKoo

Bangs

Tribioscience

BSG

技术文章
新闻动态
行业前沿
最热产品

Jackson/Peroxidase AffiniPure Goat Anti-Mouse IgG (H+L)/2.0 ml/115-035-003

Jackson/Peroxidase AffiniPure Goat Anti-Rabbit IgG (H+L)/2.0 ml/111-035-003

Qubit™ dsDNA BR Assay Kit Q32853现货

Parafilm M封口膜/PM996/4x125/整箱

Invitrogen Q32855 Qubit™ RNA HS Assay Kit现货促销

LUCK-1G,D-Luciferin, Potassium Salt 钾盐现货

GoldBio/D-Luciferin, Sodium Salt (Proven and Published™)/LUCNA-1G/1 g

Leica徕卡819一次性窄刀片【50片/盒，10盒/条】/14035838925

推荐新闻
新闻动态
行业前沿
技术文章
最新产品