Bpsbioscience/Human Interleukin-29/90187-B/20 µg188bio精品生物—专注于实验室精品爆款的电商平台

Species:Human

HostSpecies:E.coli

MW:20kDa

Genbank#:Q8IU54

a.a:24–200

Background:

TheIFN-lamBDagenefamilyiscomposedofthreedistinctgenes:IFN-lambda1(IL-29),IFN-lambda2(IL-28A),andIFN-lambda3(IL-28B).IFN-lambdaproteinsexhibitonlyweakhomologytoIL-10,but,likeIL-10,theyalsousetheIL-10R2chainasacomponentoftheirreceptorcomplex.TheIFN-receptorcomplexconsistsoftheuniqueligand-bindingchainIFN-R.TheIFN-λ1geneisfoundexclusivelyinprimategenomesandis81%identicaltoIFN-λ2/3.IFN-λs,whicharenowcollectivelyreferredtoastypeIIIIFNs,exhibitseveralfeaturesincommonwithtypeIIFNs,suchasantiviral,antiproliferative,andantitumoractivities.

Description:

RecombinantInterleukin-29(IFN-lambda)isadisulfide-linkedmonomerproteinconsistingof178aminoacidresidues,andmigratesasanapproximately20kDaproteinundernon-reducingandreducingconditionsinSDS-PAGE.OptimizedDNAsequenceencodingmurineInterleukin-29maturechainwasexpressedinE.coli.

UniProt

Q8IU54

Purity:

≥95%bySDS-PAGEandHPLC

EndotoxinLevel:

<0.1ng/µg(1EU/µg),usingtheLALgelclotmethod.

BIOLOGicalActivity:

TheED₅₀isdeterminedinananti-viralassayusinghumanHepG2cellsinfectedwithEMCVistypically1-5ng/ml.

Formulation:

Lyophilizedfrom0.2µmfilteredsolutionin130mMNaCl,20mMphosphatebuffer,pH7.5.

Format:

lyophilizedprotein

Reconstitution:

Reconstituteat0.1-1.0mg/mlindistilledwater.Thissolutioncanthenbedilutedintootherbuffers.Tomaximizeproductcollectionfromvialsurface,vortexbrieflyandthenspindowntorecollecttheliquid.

Storage/StABIlity:

Thelyophilizedproteinisstableforatleast2yearsfromdateofreceiptwhenstoredat-20°C.Uponreconstitution,storeinworkingaliquotsat+4°Cforuptoonemonth,orat-20°Cforuptosixmonths,inthepresenceofacarrierprotein.Avoidrepeatedfreeze/thawcycles.

Warning(s):

Avoidfreeze/thawcycles

AminoAcidSequence:

TSKPTTTGKGCHIGRFKSLSPQELASFKKARDALEESLKLKNWSCSSPVFPGNWDLRLLQVRERPVALEAELALTLKVLEAAAGPALEDVLDQPLHTLHHILSQLQACIQPQPTAGPRPRGRLHHWLHRLQEAPKKESAGCLEASVTFNLFRLLTRDLKYVADGNLCLRTSTHPEST

ScientificCategory:

Cytokine/GrowthFactors

ProductType:

RecombinantProtein

Datashownislot-specific.Contactusforspecificinformationonotherlots.

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Bpsbioscience/Human Interleukin-29/90187-B/20 µg