Bpsbioscience/Human Eotaxin-1 (CCL11 )/90127-B/20 µg188bio精品生物—专注于实验室精品爆款的电商平台

Species:Human

HostSpecies:E.coli

MW:9kDa

Genbank#:P51671

a.a:24–97

Background:

Eotaxinbelongstotheplateletfactor-4familyofchemokines.ThegenesymbolisSCYA11.ThefactorisbeingreferredtoalsoasEotaxin-1andhasbeenrenamedCCL11.Eotaxininducessubstantialaccumulationofeosinophilsintheskinwithoutsignificantlyaffectingtheaccumulationofneutrophils.Eotaxinisapotentstimulatorofbothguineapigandhumaneosinophilsinvitro.TheEotaxinreceptorisaG-protein-coupledreceptorselectivelyexpressedinhumaneosinophils.

Description:

RecombinantEotaxin-1isadisulfide-linkedhomodimericproteinconsistingof75aminoacidresidues,andmigratesasanapproximately9kDaproteinundernon-reducingandreducingconditionsinSDS-PAGE.OptimizedDNAsequenceencodinghumanEotaxin-1maturechainwasexpressedinE.coli.

UniProt

P51671

Synonym(s):

CCL11,SCYA11,Eotaxin-1

Purity:

≥97%bySDS-PAGEandHPLC

EndotoxinLevel:

<0.1ng/µg(1EU/µg),usingtheLALgelclotmethod.

BIOLOGicalActivity:

BiologicalactivitywasdeterminedbytheABIlitytoinducechemotaxisofpurifiedeosinophilsatconcentrationsrangingbetween50-100ng/ml.

Formulation:

Lyophilizedfrom0.2µmfilteredsolution(1mg/ml)inPBS,pH7.4.

Format:

lyophilizedprotein

Reconstitution:

Reconstituteat0.1-1.0mg/mlindistilledwater.Thissolutioncanthenbedilutedintootherbuffers.Tomaximizeproductcollectionfromvialsurface,vortexbrieflyandthenspindowntorecollecttheliquid.

Storage/Stability:

Thelyophilizedproteinisstableforatleast2yearsfromdateofreceiptwhenstoredat-20°C.Uponreconstitution,storeinworkingaliquotsat+4°Cforuptoonemonth,orat-20°Cforuptosixmonths,inthepresenceofacarrierprotein.Avoidrepeatedfreeze/thawcycles.

Reference(s):

1.Clin.CancerRes.,Apr2009,15:2647-2656.
2.Int.Immunol.,Feb2009,21:187-201.
3.J.Immunol.,Nov2008,181:7390-7399.

Warning(s):

Avoidfreeze/thawcycles

AminoAcidSequence:

GPASVPTTCCFNLANRKIPLQRLESYRRITSGKCPQKAVIFKTKLAKDICADPKKKWVQDSMKYLDQKSPTPKP

ScientificCategory:

Cytokine/GrowthFactors

ProductType:

RecombinantProtein

Datashownislot-specific.Contactusforspecificinformationonotherlots.

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Bpsbioscience/Human Eotaxin-1 (CCL11 )/90127-B/20 µg