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Stemcell/Anti-Human CD2 Antibody, Clone RPA-2.10/FITC/60007AZ.1

Overview

The RPA-2.10 antibody reacts with CD2, an ~50 kDa type I transmembrane glycoprotein and a member of the immunoglobulin (Ig) superfamily; two Ig-like domains are located in its extracellular portion. CD2 is broadly expressed on peripheral T and NK cells, dendritic cells, erythrocytes, most thymic T cells, subsets of thymic B cells, and on the endothelium. CD2 expression appears early during T cell differentiation. Aberrant expression has been observed in some lymphomas and myeloid leukemias. CD2 is critically important for T cell activation and signaling, as well as lymphocyte adhesion. The primary ligand for CD2 is CD58 (LFA-3) located on antigen-presenting cells, with additional ligands comprising CD15 (SSEA-1), CD48 and CD59. Notably, the RPA-2.10 antibody blocks the mixed lymphocyte reaction.
Subtype:
Primary Antibodies
Target Antigen:
CD2
Alternative Names:
LFA-2, SRBC-R, T11
Reactive Species:
Baboon; Capuchin Monkey; Cynomolgus; Pigtailed Macaque; Rhesus; Squirrel Monkey; Chimpanzee; Human; Pig
Conjugation:
APC; FITC; PE; PerCP
Host Species:
Mouse
Cell Type:
T Cells
Application:
Cell Isolation; Flow Cytometry; Functional Assay; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Western Blotting
Area of Interest:
Immunology
Clone:
RPA-2.10
Gene ID:
914
Isotype:
IgG1, kappa
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