Deprecated: Creation of dynamic property cls_session::$session_data_table is deprecated in /www/sites/www.188bio.com/index/systems/cls_session.php on line 49
DiscoverX/PathHunter® Tocilizumab Bioassay Kit/1000dp(10x96-well)/93-1045B3-00110188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
您好,欢迎您进入188进口试剂采购网网站! 服务热线:4000-520-616
蚂蚁淘商城 | 现货促销 | 科研狗 | 生物在线
产品资料

DiscoverX/PathHunter® Tocilizumab Bioassay Kit/1000dp(10x96-well)/93-1045B3-00110

The PathHunter Tocilizumab Bioassay is an application of the DiscoverX Dimerization Assay platform. The assay is designed to detect the ligand-induced interaction of the interleukin-6 receptor (IL-6R) with the interleukin-6 signal transducer protein (IL-6ST). The cells have been engineered to co-express IL-6ST fused to PK, and IL-6R fused to EA. Binding of an agonist to the IL-6R causes multimerization of the IL-6R and IL-6ST receptors, resulting in activation of downstream signaling events. This brings the two b-gal fragments into close proximity, forcing complementation. Heterodimerization of the two receptor chains results in the formation of a functional b-gal enzyme that hydrolyzes the substrate to generate a chemiluminescent signal. Blocking IL-6 binding with an anti-ligand or anti-receptor antibody can prevent this interaction, resulting in a loss of signal.The bioassay kit contains all reagents needed for the assay, including pre-qualified cryopreserved cells, detection reagents, cell plating reagent, positive control agonist, and assay plates.
Target/Description
interleukin 6 receptor
Group
Interleukin Receptor
Cell Background
U2OS
Species
Human
Accession Number
NM_000565.3
Agonist/Ligand
IL-6
Assay Measures
Dimerization
Bioassay Target Name
IL6R/IL6ST
Assay Qualified With
Actemra
Drug Trademark Owner
Actemra is a registered trademark of Chugai Seiyaku Kabushiki Kaisha Corp., a member of the Roche Group.
How it works
相关产品
最新签约

SBI

anchormolecular

Aviscera

Prospec

MedKoo

Bangs

Tribioscience

BSG

技术文章
新闻动态
行业前沿
最热产品

Jackson/Peroxidase AffiniPure Goat Anti-Mouse IgG (H+L)/2.0 ml/115-035-003

Jackson/Peroxidase AffiniPure Goat Anti-Rabbit IgG (H+L)/2.0 ml/111-035-003

Qubit™ dsDNA BR Assay Kit Q32853现货

Parafilm M封口膜/PM996/4x125/整箱

Invitrogen Q32855 Qubit™ RNA HS Assay Kit现货促销

LUCK-1G,D-Luciferin, Potassium Salt 钾盐现货

GoldBio/D-Luciferin, Sodium Salt (Proven and Published™)/LUCNA-1G/1 g

Leica徕卡819一次性窄刀片【50片/盒，10盒/条】/14035838925

推荐新闻
新闻动态
行业前沿
技术文章
最新产品