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Inhibitor of Wnt processing and secretion. Inactivates PORCN, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. Blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and -catenin accumulation. Suppresses self-renewal in R1 embryonic stem cells and promotes cardiomyocyte differentiation from hPSCs.
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关键词: IWP 2, IWP 2 supplier, MBOAT, membrane-bound, o-acyltransferases, Porcupine, porcn, wnt, secretion, production, signaling, signalling, inhibitors, inhibits, inactivators, inactivates, IWP2, beta-catenin, -catenin, b-catenin, stem, cell, proliferation, Stem, Cell, Signaling, Proliferation, PORCN, Organoids, Cardiomyocyte, Cells, 3533, Tocris Bioscience
Lee and Evans (2019)TMEM88 Inhibits Wnt Signaling by Promoting Wnt Signalosome Localization to Multivesicular Bodies. iScience 19 267 PMID:31401350Nakanishi et al (2019)Geometrical Patterning and Constituent Cell Heterogeneity Facilitate Electrical Conduction Disturbances in a Human Induced Pluripotent Stem Cell-Based Platform: An In vitro Disease Model of Atrial Arrhythmias. Front Physiol 10 818 PMID:31316396Walko et al (2017)A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells. Nat Commun 8 14744 PMID:28332498Vahdat et al (2019)Establishment of A Protocol for In Vitro Culture of Cardiogenic Mesodermal Cells Derived from Human Embryonic Stem Cells. Cell J 20 496 PMID:30123995Rostovskaya et al (2019)Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation. 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Stem Cell Res.Ther. 9 186 PMID:29996941et al (2016)Wnt/β-catenin signaling promotes self-renewal and inhibits the primed state transition in naïve human embryonic stem cells. Proc Natl Acad Sci U S A 113 E6382 PMID:27698112Faisy et al (2014)Wnt/β-catenin signaling modulates human airway sensitization induced by β2-adrenoceptor stimulation. PLoS One 9 e111350 PMID:25360795Kling et al (2018)Temporal Regulation of Natural Killer T Cell Interferon Gamma Responses by β-Catenin-Dependent and -Independent Wnt Signaling. Front Immunol 9 483 PMID:29616022Kennedy et al (2016)Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription. Proc Natl Acad Sci U S A 113 3545 PMID:26969725Hojo et al (2013)Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium. J Biol Chem 288 9924 PMID:23423383$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
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I use it as a blocking molecule of the WNT pathway for cardiac differentiation in foreskin fibroblast-derive IPS cells. I obtained succesfully cardiomyocytes in a 5uM concentration.
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Our GMP stem cell compounds are suitable for use as ancillary reagents (raw materials) for the further manufacturing of stem cell therapies.
Learn More Cat. No. 6775 O-GlcNAc transferase (OGT) inhibitorBio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.Bio-TechneWHERE SCIENCE INTERSECTS INNOVATIONTM